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Date:   22 November, 2011  

Focus:
 Small animals - dogs, cats, hamsters, guinea pigs, turtles & rabbits
Corneal endothelial dystrohy and ulcers in a Miniature Pinscher and a follow up 6 weeks later
Dr Sing Kong Yuen, BVMS (Glasgow), MRCVS
22 November, 2011  
toapayohvets.com 
Be Kind To Pets
Veterinary Education
Project 2010-0129
PART 1.
Sep 24, 2011

The owner wanted a diagnosis from a male vet at Toa Payoh Vets. She had been to Vet 1 who referred her to Vet 2, but she said she still had to pay Vet 1 for a "non-diagnosis". I showed her that Vet 1 did diagnose "lipid" deposits in the right eye and then referred her to Vet 2.

"It must have been a long time since I saw you," I said. I usually keep older records stored outside the Surgery. She showed me my 2006 Toa Payoh Vets receipt with my pen illustration of "left eye white central scarred ulcer - 3mm diameter". I was impressed that she kept records of her dog. It was some 5 years ago! "It was the left eye affected," she said. "The spot disappeared after a while."

"Did you use the eye ointment?" I asked.

"No," she said. "My dog disliked it. "Her ulcer disappeared without me using the eye ointment." It was good to meet up again and such reunions are happy incidents in veterinary practice as some children of my clients would have grown up to young adults or have married.

EXAMINATION
1. To check whether the right eye had corneal ulcers or not in addition to the lipid deposits.
I showed my assistant Min how I used the fluorets paper strip. I placed it onto the lower fornix and closed the eyelid. The dog blinked many times. Green dye gathered below the lower conjunctiva.

"Is it dangerous to my dog's eye?" the owner asked.
 "No," I showed her the seller was Bausch and Lomb which she had instant brand recognition. She said: "There was a lawsuit against this company for the contaminated contact lens solution." But she knew I was using a reliable approved eye dye to use on her dog's eyes. 

Results: No green ulcers in the right eye but there were 11 to 1 o'clock ulcers in the left eye!

corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore2. Digital photography useful esp. side views of corneal degeneration. Axial central corneal degeneration 4x3 mmx3mm. It looks like it is going to bulge out and ulcerate. The Owner had said the swelling suddenly appeared in the last month. But I showed her that Vet 1 had recorded that white deposits in the right eye had been seen in the Sep 2010 visit. Only that the deposits were few. 

3. Blood tests for thyroid and cholesterol not done yet due to financial considerations. Hypothyroid and high cholesterol are said to be important in this degeneration where aqueous fluid enters the endothelium, causing edema and whiteness and swelling (side view of image).

DIAGNOSIS

Right eye - corneal endothelial dystrophy. No definite cure as this is likely due to aging. Blood tests for thyroid hormones and cholesterol levels advised. "Some old people get cholesterol lumps above their eyelids," I gave an analogy but she did not know what I meant as she had not seen them.

Left eye - corneal ulcers due to eye rubbing of the 3 upper eyelid "melanomas". Excision of the melanomas will prevent ulcerations.

TREATMENT
Usually not curative. Low fat diet 8% fat? Check thyroid hormones and cholesterol levels. Prevent further corneal degeneration?
E-collar and antibiotics to prevent left eye rubbing although the owner said she never saw actual rubbing.

PART 2.
Monday, Sep 26, 2011

I review 47 images of the eyes of the fidgeting Miniature Pinscher whose owner reject injections and anaesthetics as a matter of personal preferences.

The green dye had stained the left eye 11-1 o'clock cornea a zigzagging green. I saw it. The owner saw it. But my camera techniques are lacking in that I can't capture the ulcer clearly in the operating room after application of the dye and doing hand-held. I had one respectable image. What I needed was a reflector but then Sunday was a busy day and I have not organised myself.

This morning at 8.30 am, I went through the 47 images again at home. Miniature Pinschers don't suffer from eye ulcers unlike the Shih Tzus and the Pekineses. She did have a small central eye ulcer scar of 3mm in diameter in 2006 when the owner first saw me and that was the only time I was consulted.

Clients in Singapore  doctor hop whether it is human or veterinary medicine but the vet must do his best in the diagnosis and bedside manners as well as in his receptionist services and other aspects. There are many factors involved in retaining a client's loyalty.

In any case, I was surprised that I had not seen the 3 melanomas on the upper eyelid at the 11-1 o'clock position. That is the cause of the ulcer which appeared just below these "melanomas." The 9-year-old spayed female dog felt irritated by these 3x3 mm lumps and must have tried to scratch them off. So, there was the zig zag upper corneal ulcer stained green. Vet 1 and I had not noted these melanomas as the dog kept moving. For me, the right eye was the main complaint and that was corneal degeneration/dystrophy. But the left eye was not normal as revealed by the green stain of ulcers.

The dog was moving. The owner did not want any sedation nor did I ask since she was not in favour of any injections or anaesthetics. She held the dog tightly. I muzzled the dog. Focus was on the right eye. The green ulcers in the left eye was picked up by the fluorescein dye. But what was the cause? I did say eye rubbing by the dog. The owner said: "I don't see my dog rubbing her eyes. Is the green dye poisonous?" Much of the time had been spent trying to flush away the green dye while the dog avoided by moving her head sideways. The owner tried to syringe the normal saline and said: "I wetted myself".

The owner had wanted a male vet to check her dog out. Was it Dr Jason Teo or myself she could not say. It was me 5 years ago and so it was OK with her as she did not want to go to the "referred vet". I said: "Vet 2 could be specialising in eyes and that was why Vet 1 refers you to her."

She asked if there are Singaporean veterinary eye specialists in Singapore. "Presently, there is none," I said.

corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore
  corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore

Use digital images from a good camera lens able to zoom to review eye cases later. In this case, the digital images picked up three very small melanomas that I missed during examination of the moving Miniature Pinscher

The "melanomas" were small but could be seen clearly in the image. This shows that visual aids are good for reviews and help to diagnose. The right eye is likely to suffer from a condition called corneal endothelial dystrophy which is a opacity (lipid deposits) of the inner layer of the cornea due to aging.

I phoned the owner and told her about the eyelid melanomas which can be removed by surgery if she wished. Also, the corneal endothelial dystrophy may develop into an ulcer later. A blood test to check for hypothyroidism and hypercholesterol and lipids and a low fat diet of less than 8% had been suggested. She said that her dog is on a vegetarian diet and thanked me for the call. Later, I e-mailed to her two relevant images.
 

PART 3.
Sep 28, 2011

Dear Ms ...

I am Dr Sing from Toa Payoh Vets. Thank you for your email. Attached is a brief report and 2 images of your dog's eye conditions to help you understand what is happening to your dog's eyes.

corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore1. right eye - corneal endothelial dystrophy associated with aging. It is likely due to the leakage of the aqueous from inside the eye into the endothelium and into the inside of the cornea substance. Observe for corneal ulceration which may occur later. Lipid deposit into the cornea is also likely to cause axial corneal opacity.
 
corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore2. left eye - corneal ulcers (dyed green by fluorescein) at around 11-1 o'clock due to the dog's attempt to rub off the 3 eyelid tumours, probably melanomas. The dog's eye ulceration is known as superficial keratitis. It is not serious presently. If the dog does not rub her eyes (24-hour e-collar for around 4 weeks), the ulcer will heal.

My advice is to get the suspected 3 "melanomas" excised. If you wish to know whether they are cancerous or not, a histopathology done on the tumours by the laboratory will be required. Anaesthesia in any dog including old ones carry a risk of heart failure. Blood test to screen for her health before anaesthesia is advised.    

If you can't view the eyelid tumours, let me know and I will crop the picture focusing at the left eye. Best wishes.
PART 4.
Nov 22, 2011

The owner texted me to have an appointment with her dog and we met on Sunday Nov 20, 2011. I was surprised at the good news from her.

After 6 weeks of application of a drop of eye drop  (antibiotic and steroid) daily, the owner said that the cloudiness of the inside of the cornea had lightened.  I show two before and after treatment images below. From direct observation, there is less cloudiness and the edges of the lipid layer are more defined. It seems that the density of the lipid has decreased. The owner requested another bottle of eye drops. 

In this case, the topical steroid seems to have halted the advancement of the lipid layers. There is said to be no cure for corneal dystrophy as it is related to ageing. 

As for the left eye with melanomas, the ulceration cannot be confirmed as the owner did not want any fluorescein eye stain test.
corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore corneal dystrophy, minature pinscher, toapayohvets, singapore corneal dystrophy, ulcers, eyelid melanomas - miniature pinscher, 9 years, toapayohvets, singapore corneal dystrophy, minature pinscher, toapayohvets, singapore
tpvets_logo.jpg (2726 bytes)4774. Six weeks ago. A zoom lens was used. The Canon DSLR was hand-held. Lighting was natural daylight.  tpvets_logo.jpg (2726 bytes)4775. Six weeks later. A wide-angled lens was used and appear to give better image quality tpvets_logo.jpg (2726 bytes)4776. Six weeks ago. A zoom lens was used. tpvets_logo.jpg (2726 bytes)4777. Six weeks later. This image is is of a better quality with a wide-angled lens being used. It is extremely difficult to photograph a moving dog's eye.

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Be Kind To Pets
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