Many Malaysian vets I meet during continuing education
talks have found the following effective for injectable general
anaesthesia. Here is the TKX mixture used by many Malaysian vets.
E-MAIL dated Jun 10, 2011
Hi there Dr. Sing,
For me, in terms of injectable zoletil most of us vets here uses
the TKX mixture. here is how you do it:
1. take zoletil 100
2. discard the water diluent
3. mix 2 ml of xylazine 100mg/ml
4. mix 8 ml of ketamine 100mg/ml
then you will have 10ml of TKX (zoletil plus ketamine plus xylazine)
where 0.1ml of this tkx should knock down an animal about
3kg for a decent 15-20 minutes. very good for short
procedures and also the muscles are quite relaxed unlike those
if you use in pure zoletil.
i personally use my own concoction of 3ml xylazine and 7 ml
ketamine and i find that this mixture gives me a knock down
of 20-25 minutes and the animal 'sleeps' longer. i maintain my
animals on gas if the procedure takes any longer than 15
minutes. the only worry is the chance of hypotension (due to
xylazine) and we should be mindful of older animals or those
with cardiac insufficiency.
E-MAIL dated Jun 11, 2011
With my own concoction, you may give it IM with
the same weight of 3kg but i have used it to knock a 4kg
animal down before also. 0.1ml IV will easily knock a 10kg
animal down straight into GA without any pre-med.
this TKX is good for dogs, cats and ferrets,
all given in a single syringe.
1. I have seen the above TKX used effectively in cat spays in
NANAS, an animal shelter in Johor some 2 years ago. It is said to be
safe. Do note that xylazine is 100 mg/ml, NOT 20 mg/ml as
traditionally used for dogs and cats.
2. I don't use it. I use domitor + isoflurane gas or xylazine 20
+ isoflurane gas for the past years and find that safe and effective.
The advantage is that the dog or cat wakes up within 5 minutes of the
end of surgery since isoflurane gas is eliminated fast.
3. For xylazine+ketamine IM, I find the following effective and
safe in cat spays with a analgesic duration of 15-20 minutes.
For cats 2-3 kg, I give xylazine 0.1 + ketamine 0.4 ml IM in one
For cats 3-5 kg,
I give xylazine 0.15 + ketamine 0.6 ml IM in one
For cats 5-8 kg, I give
xylazine 0.2 + ketamine 0.8 ml IM in one syringe
Isoflurane gas top up at 5% for <1 minute, to effect, when necessary.
4. Each vet has his or her own preferences. The bottom line is that
the dog or cat or pet has to walk out alive at the end of surgery and
anaesthesia. Nothing matters more than seeing a beloved companion
alive as anaesthesia risk and death are the main concern of the pet