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      Date:   13 June, 2011  

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Injectable Anaesthesia in Veterinary Medicine - The TKX mixture
Dr Sing Kong Yuen, BVMS (Glasgow), MRCVS
13 June, 2011 
Be Kind To Pets
Veterinary Education
Project 2010-0129
Many Malaysian vets I meet during continuing education talks have found the following effective for injectable general anaesthesia. Here is the TKX mixture used by many Malaysian vets. 
E-MAIL dated Jun 10, 2011

Hi there Dr. Sing,

For me, in terms of injectable zoletil most of us vets here uses the TKX mixture. here is how you do it:

1. take zoletil 100
2. discard the water diluent
3. mix 2 ml of xylazine 100mg/ml
4. mix 8 ml of ketamine 100mg/ml

then you will have 10ml of TKX (zoletil plus ketamine plus xylazine) where 0.1ml of this tkx should knock down an animal about 3kg for a decent 15-20 minutes. very good for short procedures and also the muscles are quite relaxed unlike those if you use in pure zoletil.

i personally use my own concoction of 3ml xylazine and 7 ml ketamine and i find that this mixture gives me a knock down of 20-25 minutes and the animal 'sleeps' longer. i maintain my animals on gas if the procedure takes any longer than 15 minutes. the only worry is the chance of hypotension (due to xylazine) and we should be mindful of older animals or those with cardiac insufficiency.

E-MAIL dated Jun 11, 2011

With my own concoction, you may give it IM with the same weight of 3kg but i have used it to knock a 4kg animal down before also. 0.1ml IV will easily knock a 10kg animal down straight into GA without any pre-med.
this TKX is good for dogs, cats and ferrets, all given in a single syringe.

1.  I have seen the above TKX used effectively in cat spays in NANAS, an animal shelter in Johor some 2 years ago. It is said to be safe. Do note that xylazine is 100 mg/ml, NOT 20 mg/ml as traditionally used for dogs and cats.

2.  I don't use it. I use domitor + isoflurane gas or xylazine 20 + isoflurane gas for the past years and find that safe and effective. The advantage is that the dog or cat wakes up within 5 minutes of the end of surgery since isoflurane gas is eliminated fast.

3.  For xylazine+ketamine IM, I find the following effective and safe in cat spays with a analgesic duration of 15-20 minutes.

For cats 2-3 kg, I give xylazine 0.1 + ketamine 0.4 ml IM in one syringe
For cats 3-5 kg,
I give xylazine 0.15 + ketamine 0.6 ml IM in one syringe  
For cats 5-8 kg, I give xylazine 0.2 + ketamine 0.8 ml IM in one syringe
Isoflurane gas top up at 5% for <1 minute, to effect, when necessary.  

4. Each vet has his or her own preferences. The bottom line is that the dog or cat or pet has to walk out alive at the end of surgery and anaesthesia. Nothing matters more than seeing a beloved companion alive as anaesthesia risk and death are the main concern of the pet owner.

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